pentobarbital will decrease the extent or outcome of tramadol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Lowered AUC of tramadol as well as Energetic metabolite (O-desmethyltramadol) when coadministered with robust CYP3A4 and CYP2B6 inducersThe effect of barbiturates on the metabolism of phenytoin appears f